Advanced Therapies
Two Approaches. One Standard of Care.
Next Health offers two distinct Advanced Therapy categories: a coordinated Restoration Protocol combining plasma exchange, hyperbaric oxygen therapy, and NAD+ IV therapy for systemic wellness optimization; and Joint Therapies using PRP and restorative molecules for musculoskeletal applications. Both delivered under physician supervision.
Two distinct service offerings under one care category
Restoration Protocol available at select Next Health locations
All Advanced Therapies delivered under physician supervision
Why Advanced Therapies
The advanced restorative therapies category has a credibility problem. We built our offering around the things that actually have evidence.
Advanced restorative therapies have become one of the most overpromised categories in healthcare. Clinics across the country market stem cell therapies for conditions where there is no clinical evidence to support them, charge thousands of dollars for treatments with no mechanism, and operate outside the regulatory boundaries that protect patients in conventional medicine.
That has made the category genuinely risky for patients trying to evaluate what might actually help them. It has also obscured the fact that a small subset of advanced therapies — therapies with mechanism, with research support, and with appropriate clinical context — are legitimately valuable parts of a longevity and wellness program.
Next Health offers two categories of advanced therapies that meet that bar. The first is our Restoration Protocol — a coordinated combination of TPE, HBOT, and NAD+ IV therapy delivered as a structured program over time. This is not stem cell therapy. This is not a regeneration claim. This is a wellness optimization protocol that targets specific biological systems with therapies that have decades of clinical research behind them.
The second is Joint Therapies — PRP and restorative molecule injections for joint applications, delivered by qualified clinicians, in a clinical environment, with clear discussion of what the therapies can and cannot accomplish. We do not offer stem cell joint injections, and we do not make claims about regenerating cartilage or reversing joint disease.
Dr. Darshan Shah, MD
Founder & Chief Medical Officer, Next Health
What's Included
Two Categories of Advanced Therapy.
The Restoration Protocol is a structured wellness optimization program. Joint Therapies are targeted musculoskeletal applications. The two serve different patients and address different clinical situations.
Offering 01
The Restoration Protocol
A coordinated wellness optimization protocol combining three advanced therapies — delivered at select Next Health locations.
Therapeutic Plasma Exchange (TPE)
TPE is a clinical procedure that filters and replaces the plasma component of your blood. Your blood is drawn through an IV, passed through a centrifuge that separates plasma from cellular components, and the cellular components are returned with replacement fluids. The procedure takes two to four hours under physician supervision.
TPE is FDA-approved for specific medical conditions. The wellness application of TPE in the Restoration Protocol is investigational and is not a treatment for any specific disease.
Hyperbaric Oxygen Therapy (HBOT)
HBOT delivers oxygen at greater than atmospheric pressure in an enclosed chamber, increasing the amount of oxygen your blood can carry to tissues. Sessions typically last 60 to 90 minutes. Patients lie comfortably in the chamber during treatment under technician supervision.
HBOT is FDA-cleared for 14 specific medical conditions. The wellness application of HBOT in the Restoration Protocol is off-label and is not a treatment for any specific disease.
NAD+ IV Therapy
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme essential to cellular energy production. NAD+ IV therapy delivers NAD+ directly into the bloodstream, bypassing the digestive system. Sessions typically take two to four hours. Patients sit comfortably during the infusion.
NAD+ is a nutritional supplement delivered intravenously. NAD+ IV therapy is not approved by the FDA for the treatment of any specific medical condition.
The Restoration Protocol combines these three therapies in a structured program over time. Specific protocol design, frequency, and sequencing are determined by your Next Health physician based on your individual situation.
Schedule a Restoration ConsultationOffering 02
Joint Therapies
Targeted biologic injections for joint applications, using PRP and restorative molecules — delivered by qualified Next Health clinicians.
Platelet-Rich Plasma (PRP) Injections
PRP injections use platelets concentrated from your own blood to deliver growth factors directly to a target joint. A small volume of your blood is drawn, processed in a centrifuge to concentrate the platelets, and the resulting PRP is injected into the joint by a qualified clinician. The procedure takes approximately one hour from start to finish.
PRP joint injections are a clinical procedure performed by qualified Next Health clinicians. Specific outcomes vary by patient. PRP injections are not a treatment for any specific disease and are not a substitute for conventional medical evaluation or surgical consultation when indicated.
Restorative Molecule Injections
Beyond PRP, Next Health offers additional restorative molecule injection options for joint applications. These include specific growth factor preparations and biologic agents delivered directly to the target joint by qualified clinicians. The specific molecule selection is determined by your clinician based on your individual situation.
Restorative molecule injections are clinical procedures performed by qualified Next Health clinicians. Specific outcomes vary by patient. These injections are not a treatment for any specific disease and are not a substitute for conventional medical evaluation when indicated.
Joint Therapy candidacy is determined by clinical evaluation. Not every patient is an appropriate candidate, and your screening consultation determines whether Joint Therapies are right for your specific situation.
Schedule a Joint Therapy ConsultationThe Science
What These Therapies Actually Do.
Both offerings work through specific biological mechanisms. Here's what each one targets — described accurately, with research attributed to the appropriate sources.
Restoration Protocol
Plasma Exchange Mechanism
TPE filters the plasma component of your blood — the fluid that carries proteins, lipids, antibodies, and various cellular debris. Published research has investigated TPE in multiple wellness applications. The wellness application of TPE is an active area of clinical research.
Hyperbaric Oxygen Mechanism
HBOT increases the partial pressure of oxygen in your blood, which can carry oxygen to tissues that ordinarily receive less. Published research has investigated wellness applications of HBOT including studies on tissue function and biological aging biomarkers.
NAD+ Mechanism
NAD+ is a coenzyme that plays a central role in cellular energy production through participation in mitochondrial function and DNA repair processes. NAD+ levels naturally decline with age, and supplementation research has investigated whether restored NAD+ levels affect cellular function.
Joint Therapies
PRP Mechanism
PRP uses concentrated platelets from your own blood to deliver growth factors directly to target tissues. The growth factors include PDGF, TGF-β, VEGF, and others — molecules involved in tissue healing processes. PRP for joint applications has been studied in clinical research for decades.
Restorative Molecule Mechanism
Specific restorative molecule preparations work through different mechanisms depending on the molecule. Growth factor preparations deliver concentrated tissue-healing factors. Biologic preparations work through cellular signaling mechanisms. The specific molecules used at Next Health are selected based on clinical evidence and your individual situation.
Specific outcomes vary by patient. Specific research findings belong to the cited research groups, not to Next Health.
What These Therapies Target
Biological Systems and Clinical Applications.
Different therapies target different biological systems. The Restoration Protocol targets systemic biology. Joint Therapies target localized musculoskeletal applications.
Restoration Protocol targets:
- Plasma composition — TPE addresses the proteins, lipids, and accumulated materials in the plasma fraction of blood.
- Cellular energy production — NAD+ targets mitochondrial function through coenzyme support.
- Oxygen delivery and tissue oxygenation — HBOT addresses oxygen availability to tissues.
- Inflammatory pathways — multiple components of the protocol have been studied for their effects on inflammatory markers.
- Systemic biological markers associated with aging — research has investigated whether the protocol's combined components affect biological aging biomarkers.
Joint Therapies target:
- Local tissue healing processes — PRP delivers growth factors involved in tissue repair.
- Joint biomechanics — the procedures aim to support joint function, though specific outcomes vary by patient.
- Pain management — many patients pursuing Joint Therapies are seeking biologic approaches to joint discomfort, though specific pain outcomes vary.
- Recovery from joint stress — Joint Therapies are commonly pursued by athletes, active adults, and patients recovering from joint strain.
Transparent Scope Disclosure
What These Therapies Are — and What They Are Not.
What These Therapies Are
- ✓Wellness optimization therapies delivered as part of a longevity-focused care approach at Next Health.
- ✓Delivered under physician supervision at Next Health locations by qualified clinicians.
- ✓Targeting specific biological systems with mechanisms described in published clinical research.
- ✓Subject to individual clinical evaluation — your candidacy and protocol design are determined by your Next Health provider based on your specific situation.
- ✓Appropriate for adults pursuing comprehensive wellness optimization or specific joint applications, who understand that specific outcomes vary by patient.
What These Therapies Are Not
- —Not a treatment, cure, or prevention for any specific disease — including Alzheimer's disease, arthritis, autoimmune conditions, or any other condition unless FDA-approved for that specific indication.
- —Not stem cell therapy. Next Health does not offer stem cell injections for any application, including joint applications.
- —Not a substitute for conventional medical evaluation. Patients with diagnosed conditions should continue to be managed by their treating physicians.
- —Not a substitute for surgical consultation when surgery is clinically indicated. Joint Therapies are not marketed as alternatives to surgery.
- —Not FDA-approved for wellness applications. TPE and HBOT have specific FDA-approved indications; the wellness applications offered in the Restoration Protocol are off-label.
- —Not appropriate for everyone. Your screening consultation determines candidacy.
Is This Right For You?
Four Patient Profiles.
The Longevity-Focused Adult
Adults pursuing a comprehensive wellness optimization approach. The Restoration Protocol is part of a broader Next Health longevity strategy that may also include the Executive Physical, ReCODE Program, and other Next Health services.
The Active Adult With Joint Concerns
Athletes, active adults, and patients experiencing joint discomfort or limitation who are seeking biologic injection options. Joint Therapies are pursued as part of broader joint care, often alongside physical therapy or other conventional approaches.
The Patient Recovering From Specific Stress
Patients recovering from specific physical stressors — surgery, injury, intensive training — where biologic support may be appropriate. Both the Restoration Protocol and Joint Therapies are pursued in this context depending on the specific situation.
The Existing Next Health Patient Adding Advanced Care
Existing Next Health members or patients adding advanced therapies to their broader care plan. The Restoration Protocol integrates naturally into Apex+ care; Joint Therapies are pursued individually as the clinical situation warrants.
What To Expect
From Screening to Treatment to Follow-Up.
Screening Consultation
Your Advanced Therapies experience begins with a 30–45 minute screening consultation with a Next Health physician covering your full medical history, current medications, goals, and clinical situation. The consultation determines candidacy for the Restoration Protocol, Joint Therapies, or both.
Personalized Protocol Design
If you are an appropriate candidate, your Next Health physician designs your personalized protocol. For Restoration Protocol candidates: which components, in what sequence, at what frequency. For Joint Therapy candidates: which therapy approach, for which joint(s), at what intervals.
Treatment Delivery
Treatment is delivered at a Next Health location qualified for the specific therapy. Restoration Protocol patients complete TPE, HBOT, and NAD+ IV sessions according to their personalized schedule. Joint Therapy patients receive PRP or restorative molecule injections at scheduled intervals — all under physician supervision.
Ongoing Clinical Oversight
Throughout your treatment course, your Next Health physician monitors your response and adjusts the protocol as appropriate. Side effects, complications, or unexpected responses are discussed and managed clinically.
Follow-Up and Integration
After your initial treatment course, your physician reviews your overall response and discusses whether continued treatment, modifications, or different approaches are appropriate. Advanced Therapies often integrate with broader Next Health care.
Pricing and Booking
Transparent Pricing. Personalized to Your Protocol.
Advanced Therapies pricing depends on your personalized protocol — which components, how many sessions, what frequency. Your screening consultation provides a complete cost picture for your specific situation.
Restoration Protocol
Personalized protocol combining TPE, HBOT, and NAD+ IV therapy. Specific protocol design determines total cost.
Cost varies — discussed in your screening consultation.
Schedule a Restoration ConsultationJoint Therapies
PRP or restorative molecule injection for specific joint applications. Cost varies by joint(s) treated and protocol.
Cost varies — discussed in your screening consultation.
Schedule a Joint ConsultationNext Health members (Optimize 4.0, Premier 4.0, and Apex+) receive member pricing on Advanced Therapies. The Restoration Protocol integrates naturally into Apex+ care plans. Advanced Therapies are paid out-of-pocket; wellness applications are generally not covered by traditional insurance. HSA/FSA eligibility varies.
Frequently Asked Questions
Advanced Therapies, Answered.
Explore More At Next Health
Services That Often Combine With Advanced Therapies.
Apex+ Concierge
Year-long physician-led longevity care. The Restoration Protocol integrates naturally as part of your broader Apex+ care plan.
Learn About Apex+The Executive Physical
Comprehensive baseline evaluation. Many patients pursuing Advanced Therapies start with the Executive Physical to establish a complete baseline before treatment.
Learn About the EPFunctional Medicine Panel
Comprehensive biomarker evaluation. Often informs Advanced Therapy candidacy and protocol design.
Explore the PanelReady To Learn More?
Advanced Therapies Begin With a Conversation.
Schedule a screening consultation with a Next Health physician. We'll discuss your situation, your goals, and which path — if any — is right for you.
Advanced Therapies at Next Health include the Restoration Protocol (combining Therapeutic Plasma Exchange, Hyperbaric Oxygen Therapy, and NAD+ IV therapy) and Joint Therapies (using Platelet-Rich Plasma and other restorative molecules). These therapies are wellness optimization protocols delivered under physician supervision. They are not treatments, cures, or preventions for any specific disease — including Alzheimer's disease, dementia, arthritis, autoimmune conditions, or any other diagnosed condition. Next Health does not offer stem cell therapy. TPE and HBOT are FDA-approved or FDA-cleared for specific medical conditions; their use in the Restoration Protocol is investigational and off-label. NAD+ IV therapy is a nutritional supplement and is not FDA-approved for the treatment of any specific medical condition. PRP and restorative molecule joint injections are clinical procedures performed by qualified clinicians; specific outcomes vary by patient and are not substitutes for conventional medical evaluation or surgical consultation when indicated. Individual candidacy for any Advanced Therapy is determined by clinical evaluation. Please review our complete Medical Disclaimer for additional information.